Iodine works incredibly fast. You only need one drop under your tongue, let it sit 30-60 seconds, then wash it down with water. You may get a small and nasty drainage, but don't worry, that's normal (spit the drainage out immediately as that's the garbage inundating your pineal gland). If you intend to continue use for maintenance , add a drop to a glass of water once a week. As an aside; women over 50 years of age should avoid this method as it may cause thyroid issues after extended use.